S Self-medication is the first effort to self-cure or relieve mild illnesses without consulting to a medical practitioner by using Over the Counter (OTC) drugs. Oral ulcer and pulpitis are two types of oral health problems that are frequently cured with self-medication. Previous studies reported that self-medication practiced by college students are irrational. However, there is dearth of information about the profile of self-medication practices for oral health problems among college students in Indonesia. Objective: to describe the profile of self-medication practices for oral ulcer and pulpitis among college students in Jakarta. Method: this descriptive study used cross-sectional design approach. The subjects were non-healthcare college students taken from 3 universities in Jakarta. The data were collected using questionnaire. Results: The subjects were 263 consenting respondents. All 100% subjects had experience with self- medication to cure their illnesses. The most common information source for self- medication was family or friends (35,7%). Majority of the subjects obtained drugs used for self-medication from pharmacy (83,3%). Study showed, 99,2% subjects always self-medicating for oral ulcer and 48,5% for pulpitis. Majority of the subjects (64,3%) thought that self-medication practice was harmless. However, the knowledge about appropriate self-medication was poor. Conclusion: Self-medication practiced by non-healthcare college students were found to be irrational in this study. Hence, the education about appropriate self- medication and strict control of illegal prescription drugs are needed to obtain the benefits of self-medication.