A Ameloblastic Fibrosarcoma is an extremely rare odontogenic tumor,composed of benign epithelial odontogenic component and the malignantmesenchymal component, generally considered as the malignant counterpart of theAmeloblastic Fibroma. Etiology and pathogenesis of Ameloblastic Fibrosarcomacould be growed from benign tumour, which transformed into malignant, since initialhas malignancy, or from recurrent Ameloblastic Fibroma. A great quantities ofknowledge from the dentists about pathology of tumor, such as clinical features,histopathological characteristics, and the treatment techniques, will give greatbenefits in developing the right diagnose for Ameloblastic Fibrosarcoma anddifferentiated from other diseases which is characterized by almost same kind offeatures, in order to the consideration of therapy procedures can be determinedfurthermore, such as radical surgical excision or radical resection seemed to be thetreatment of choice at the meantime.