B Background: Nanofiller composite resin is one of the resin composite materialsthat is commonly used for teeth restoration because it has good mechanical andaesthetic properties. In its attachment to the tooth structure, composite resin requiresa material called bonding, so that the quality of the composite resin material as arestorative material increased, and can create a good bond between the tooth andthe bonding material. One of the criteria for assessing the bonding strength of acomposite resin restoration with dental hard tissues can be measured using the shearbond strength test. Objective: To determine the effect of generation IV anduniversal bonding (total-etch, self-etch) on the shear bond strength of nanofillercomposite resin on the enamel surface. Methods: 30 premolars mandibular wereused. The teeth were assigned into three groups. Each group consists 10 premolarsmandibular. In the first group, bonding IV generation was used. Bonding universalwere used in the second, and the third group. The application of bonding in thesecond group was applied with total-etch system, and the third group was appliedwith self-etch system. After bonding application, a nanofiller composite resin wasapplied into the enamel surface. The samples were placed in incubator for 24 hoursat 37ËšC. Shear bond strength was measured using universal testing machine withthe crosshead speed of 0.5 mm/min. Results: The highest bond strength was seenin the first group with 13,88 MPa, followed by the second group with 8,85 MPa,and the third group with 8,46 MPa. Based on the one-way ANOVA and post-hocTuckey HSD tests, there was a significant difference (p<0.05) on the shear bondstrength. The results showed that the first group with bonding generation IV had asignificant difference with the third group with universal bonding (self-etch).Conclusion: There is an effect of generation IV bonding and universal bonding(total-etch, self-etch) on the shear bond strength of nanofiller composite resin onenamel.