P Periodontal disease is mostly caused by in e action between bacterial plaque and its products, and attribute to in a ory proces . In general, the patients have poor oral hygiene and usually effort to motivate them in short time failed and the inflammatory condition becomes even more progressive. Ibuprofen is a propionic acid derivative of non steroidal anti-inflammatory drugs which has prominent anti-inflanmatory effects beside having analgesic and antipyretics actions. Ibuprofen can effectively eliminated symptoms of periodontal disease and can also inhibited periodontal bone loss. The mechanism of action of ibuprofen is to inhibit the biosynthesis of prostaglandin through the competition with cyclooxygenases.