A As WHO’ suggestion, traditional herbal medicine is very useful formodern society especially in medical field. Morinda citrifolia as traditionalherbal medicine has been proved in its usage to help the human organicsynthesizing, recover cells by its active content. However, there haven’t beenany studies yet about the effect of Morinda citrifolia solution topical applicationinto the socket on the granulation tissues degradation and collagen fibersformation. Objective: The aim of this study was to find out the effect ofMorinda citrifolia solution topical application into rat’s dental socket on thegranulation tissues degradation and collagen fibers formation. Methods:Thirty five of three months male Wistar’s rats were divided into three groups,namely control, Povidone Iodine and Morinda citrifolia with severalconcentration groups. Freezed drying Morinda citrifolia diluted into aquades tofind 1 %,2%,5%,7% and 10% solution. After tooth extraction, Morinda citrifoliagroups were applied with several concentration of Morinda citrifolia solutioninto dental socket and Povidon Iodine group was applied with Povidon Iodine10% solution. The histological examination was done on the seven days afterextraction, with parameters: the comparison between granulation tissuesdegradation and collagen fibers formation. The data were analyzedstatistically by Kruskall Wallis and Multiple Comparison test. Results:Statistical analysis with Kruskal-Wallis and Multiple Comparison test indicatedthere were significant differences (p<0,01) between control, Povidon Iodinegroups and Morinda citrifolia groups.